may include direct pulp capping, indirect pulp capping if the tissue is not fully exposed, and partial or total pulpotomy; this permits the preservation of the vitality of the tooth, its nociceptive functions, and the defense system of the body itself. Moreover, the resin in pulp capping materials such as ACTIVA BioACTIVE BASE/LINER would presumably shift the regeneration-inflammation balance towards the latter. Methods for biomimetic remineralization of human dentine: A systematic review. Pulp capping Material • 1- Calcium Hydroxide Ca(OH)2. ; Bjørndal, L.; Maltz, M.; Manton, D.J. Zeid, S.T.A. Poggio, C.; Lombardini, M.; Colombo, M.; Beltrami, R.; Rindi, S. Solubility and pH of direct pulp capping materials: A comparative study. Mineral Trioxide Aggregate (MTA) vs. Calcium Hydroxide in Direct Pulp Capping—Literature Review. Sinkar, R.; Patil, S.; Jogad, N.; Gade, V. Comparison of sealing ability of ProRoot MTA, RetroMTA, and Biodentine as furcation repair materials: An ultraviolet spectrophotometric analysis. 2016;28:58–67. ; Goodis, H.E. ; Banerjee, A. Lee, H.; Shin, Y.; Kim, S.-O. Gandolfi, M.G. ; Du, T.F. Stencel, R.; Kasperski, J.; Pakiela, W.; Mertas, A.; Bobela, E.; Barszczewska-Rybarek, I.; Chladek, G. Properties of experimental dental composites containing antibacterial silver-releasing filler. Oral Radiol. Direct pulp capping is used when the pulp is visibly exposed (vital pulp exposure) due to caries, trauma, or iatrogenic insult such as accidental exposure during tooth preparation or caries removal. A correlation of in vitro and in vivo data revealed that, currently, the most validated material for pulp capping procedures is still MTA. ; Lim, K.C. European Society of Endodontology position statement: Management of deep caries and the exposed pulp. Calcium hydroxide pastes: Classification and clinical indications. The clinical applications of mineral trioxide aggregate.  |  Pulp capping materials modulate the balance between inflammation and regeneration. A randomized controlled evaluation of posterior resin restorations of an altered resin modified glass-ionomer cement with claimed bioactivity. Despite Biodentine’s superiority in relatively easier manipulation, competitive pricing and predictable clinical outcome, more long-term clinical studies on Biodentine as a pulp capping agent are needed. ; Abrantes, A.M.; Casalta-Lopes, J.; Gonçalves, A.C.; Sarmento-Ribeiro, A.B. Nagi, S.M. To determine their clinical efficacy, further studies are needed. ; Siboni, F.; Prati, C. Chemical-physical properties of TheraCal, a novel light-curable MTA-like material for pulp capping. Available online: Jun, S.-K.; Lee, J.-H.; Lee, H.-H. ; Pallesen, U.; Benetti, A. OBJECTIVE: a) Preserve the vitality of the pulp by completely removing the carious infected dentin followed by placement of a material that would … Long-term Pulpal and Restorative Outcomes of Pulpotomy in Mature Permanent Teeth. ; Omar, N.; Salem, H.N. One study of indirect pulp capping recorded success rates of 98.3% and 95% using bioactive tricalcium silicate [Ca3SiO5]-based dentin substitute and light-activated calcium hydroxide [CA(OH)2]-based liner respectively. ; Yu, V.S.H. Nevertheless, calcium hydroxide has some drawbacks like tunnel defect during dentinal bridge formation, poor bonding to dentin, material resorption and mechanical instability. Direct pulp capping with mineral trioxide aggregate: An observational study. ; Pfefferle, T. Mineral Trioxide Aggregate or Calcium Hydroxide Direct Pulp Capping: An Analysis of the Clinical Treatment Outcome. The shear bond strength of MTA with three different types of adhesive systems: An in vitro study. I place a small increment and then spread it with the tip of a perio probe. Comparison of the physical and mechanical properties of MTA and portland cement. Help us to further improve by taking part in this short 5 minute survey, Establishment of Collagen: Hydroxyapatite/BMP-2 Mimetic Peptide Composites, Effects of Surface Treatments of Glass Fiber-Reinforced Post on Bond Strength to Root Dentine: A Systematic Review, Effect of Temperature on Deformation and Fatigue Behaviour of A356–T7 Cast Aluminium Alloys Used in High Specific Power IC Engine Cylinder Heads, Glass Fiber Reinforced Composite Orthodontic Retainer: In Vitro Effect of Tooth Brushing on the Surface Wear and Mechanical Properties, Composite and Polymeric Materials for Dentistry: Enhancing Antimicrobial and Mechanical Properties, http://www.oraverse.com/bio/img/Biodentine-ScientificFile.pdf, https://secureservercdn.net/198.71.233.195/91d.e9f.myftpupload.com/wp-content/uploads/2019/12/XF-VWP8-REV10.19.pdf, http://creativecommons.org/licenses/by/4.0/, Light-curing single paste: resin bis-phenyl glycidyl methacrylate (BisGMA) & polyethylene glycol dimethacrylate (PEGD) modified calcium silicate filled with CaO, calcium silicate particles (type III Portland cement), Sr glass, fumed silica, barium sulphate, barium zirconate, Diurethane dimethacrylate. 2017 Nov;43(11):1786-1791. doi: 10.1016/j.joen.2017.06.025. 1201-1206. In Vitro 2010. An alternative procedure to extraction or endodontic therapy is pulp capping, in which a medicament is placed directly over the exposed pulp (direct pulp cap), or a cavity liner or sealer is placed over residual caries (indirect pulp cap) in an attempt to maintain pulp vitality and avoid the more extensive treatment dictated by extraction or endodontic therapy. Siboni, F.; Taddei, P.; Prati, C.; Gandolfi, M.G. • 4- Bioaggregate. Endod. J. Tulumbaci, F.; Almaz, M.E. Marchi JJ, de Araujo FB, Fröner AM, Straffon LH, Nör JE. Shear Bond Strengths of Different Adhesive Systems to Biodentine. Akhavan Zanjani, V.; Tabari, K.; Sheikh-Al-Eslamian, S.M. Chailertvanitkul, P.; Paphangkorakit, J.; Sooksantisakoonchai, N.; Pumas, N.; Pairojamornyoot, W.; Leela-apiradee, N.; Abbott, P.V. 2019;52:949–973. ; Hebling, J.; Hanks, C.T. Giraud, T.; Jeanneau, C.; Bergmann, M.; Laurent, P.; About, I. Tricalcium Silicate Capping Materials Modulate Pulp Healing and Inflammatory Activity In Vitro. Over a 6-month observation, MTA and BD showed success rates (subjective symptoms, pulp sensibility tests and radiographic appearance) of 91.7% and 83.3%, respectively [, Based on a cell/tissue culture model, it can be concluded that materials used in pulp capping procedures directly affect the regeneration potential of the dental pulp by modulating the secretion of factors such as TGF-β1 [, Due to unsatisfactory aesthetics and physical properties of Biodentine, there is a need for an overlying material with final restoration, usually a composite. A material’s ability to remineralize tooth’s structure is associated with the resin formula of TheraCal LC that possesses calcium and hydroxide ion release properties. Effect of different surface treatment protocols on the shear bond strength of perforation repair materials to resin composite. Several materials have been used for this procedure. Analysis of organic components in resin-modified pulp capping materials: Critical considerations. If the pulp appears infected or symptomatic, the dentist may decide a root canal is the best treatment option. This comparatively new biomaterial is claimed to possess properties similar to MTA and is currently being explored for vital pulp therapy procedures. ; Yadlapati, M.; Dorn, S.O. A comparison of the remineralizing potential of dental restorative materials by analyzing their fluoride release profiles. ; writing—original draft preparation, M.L.-S. and M.K. De Souza, L.C. In Vivo evaluation of the inflammatory response and IL-6 immunoexpression promoted by Biodentine and MTA Angelus. The pulp healing process: From generation to regeneration. A correlation of in vitro and in vivo data revealed that, currently, the most validated material for pulp capping procedures is still MTA. Antibacterial activity of pulp capping materials e585 Several materials such as calcium hydroxide-based materials and more recently mineral trioxide aggrega-te (MTA) are commonly used as pulp-capping agents. ; Abou Neel, E.A. Barszczewska-Rybarek, I.; Chladek, G. Studies on the curing efficiency and mechanical properties of bis-GMA and TEGDMA nanocomposites containing silver nanoparticles. direct pulp capping; indirect pulp capping; ProRoot MTA; MTA Angelus; retroMTA; biodentine; theraCal LC; ACTIVA BioACTIVE; vital pulp therapy. ; Abrandabadi, A.N. Two types of pulp-capping materials, calcium hydroxide and mineral trioxide aggregate, have been ; Alothmani, O.S. As a response to the disadvantages of MTA, a new tricalcium silicate-based cement Biodentine (Septodont, France) was released in 2011. Nevertheless, to this day there is insufficient evidence and there have been too few clinical studies to support its reliability in vital pulp therapies. Therefore, the null hypothesis was accepted. Tunnel defects in dentin bridges: Their formation following direct pulp capping. Toxic to pulp cells due to resin component? Biodentine. ; Song, H.-J. NA—not available; SE—self-etch; DBA—dentine bonding agent. Properties of NeoMTA plus and MTA plus cements for endodontics. Tanalp, J.; Karapınar-Kazandağ, M.; Dölekoğlu, S.; Kayahan, M.B. NA—not available; E&R—etch and rinse; 2-SE—two-step self-etch; DBA—dentine bonding agent; SBS—shear bond strength. Hilton, T.J. Keys to Clinical Success with Pulp Capping: A Review of the Literature. ; Ramírez, V.; Mercade, M. Direct Pulp Capping with Calcium Hydroxide, Mineral Trioxide Aggregate, and Biodentine in Permanent Young Teeth with Caries: A Randomized Clinical Trial. This systematic review is reported using the PRISMA guidelines (Moher et al. Giraud, T.; Jeanneau, C.; Rombouts, C.; Bakhtiar, H.; Laurent, P.; About, I. ; Michou, S.; Larsen, L.; Peutzfeldt, A.; Pallesen, U.; van Dijken, J.W.V. Pornamazeh, T.; Yadegari, Z.; Ghasemi, A.; Sheykh-al-Eslamian, S.M. • - Adhere well to dentin and restorative material. Comparison of Setting Time, Compressive Strength, Solubility, and pH of Four Kinds of MTA. Res. ; Ricketts, D.; Van Landuyt, K.; Banerjee, A.; Campus, G.; Doméjean, S.; et al. The article is aimed at analyzing the available research and comparing the properties of bio-inductive materials in direct and indirect pulp capping procedures. Indeed, recent consensus reports have stated that the complete or nonselective carious removal is now considered overtreatment [, Six different bioactive materials have been described and compared: four calcium-silicate cements—ProRoot MTA (Dentsply Sirona, York, PA, USA), MTA Angelus (Angelus, Londrina, Brazil), RetroMTA (BioMTA, Seoul, Korea) and Biodentine (Septodont, Saint-Maur-des-Fossés, France); a light-cured calcium silicate-based material TheraCal LC (Bisco, Schaumburg, IL, USA); and a resin-modified glass-ionomer (RMGIC) with improved resilience and physical properties—ACTIVA BioACTIVE (Pulpdent Corporation, Watertown, MA, USA) [. Jeanneau, C.; Laurent, P.; Rombouts, C.; Giraud, T.; About, I. Light-cured Tricalcium Silicate Toxicity to the Dental Pulp. The effect of various mixing techniques on the surface microhardness of mineral trioxide aggregate. Biological effects and washout resistance of a newly developed fast-setting pozzolan cement. The properties and clinical performances of four calcium-silicate cements (ProRoot MTA, MTA Angelus, RetroMTA, Biodentine), a light-cured calcium silicate-based material (TheraCal LC) and an enhanced resin-modified glass-ionomer (ACTIVA BioACTIVE) are widely discussed. Int Endod J. However, the long setting time and also high cost have urged the development of new types of MTA-based materials to overcome these drawbacks (, The biocompatibility and sealing ability of MTA result from the dominant calcium ion released from the material which reacts with phosphates in tissue fluid, inducing hydroxyapatite formation (, The first formulation of MTA was grey, but due to the reported discoloration of teeth [, In addition, MTA is less toxic, easier to use in pulp capping procedures and causes less pulpal inflammation than Ca(OH), Other key factors for successful pulp capping procedures are the ability of the bioactive material to seal to the tooth structure, the bond strength between the pulp capping material and restorative properties (, Alternation in material characteristics has recently led to development of new generation MTA-based cements; namely, Neo MTA Plus (Avalon Biomed Inc., Houston, TX, USA) and the iRoot (Innovative BioCeramix Inc., Vancouver, BC, Canada) products family. Human Pulp Responses to Partial Pulpotomy Treatment with TheraCal as Compared with Biodentine and ProRoot MTA: A Clinical Trial. ; Ricucci, D.; Saoud, T.M. Fathy, S. Remineralization ability of two hydraulic calcium-silicate based dental pulp capping materials: Cell-independent model. Reactions of Subcutaneous Connective Tissue to Mineral Trioxide Aggregate, Biodentine®, and a Newly Developed BioACTIVE Base/Liner. ; Gokdogan, F.G.; Gundogdu, E. Clinical and radiographic outcomes of direct pulp capping therapy in primary molar teeth following haemostasis with various antiseptics: A randomised controlled trial. ; Duncan, H.F. Management of deep caries and the exposed pulp. ; Pitt Ford, T.R. ; Lumley, P.J. ; Yang, Y.; Ma, J.; Haapasalo, M. Physical properties and hydration behavior of a fast-setting bioceramic endodontic material. As in the other light-cured tricalcium silicate, incomplete resin photopolymerization may lead to free monomers’ release, and consequently to pulpal toxicity [, Development of minimally invasive biologically based therapies aimed at preservation of the pulp vitality remains the key theme within contemporary clinical endodontics. Benetti, A.R. It is intended to protect the pulp and be used in deep areas of decay for indirect and direct pulp capping. Ha, W.N. Kamal, E.; Nabih, S.; Obeid, R.; Abdelhameed, M. The reparative capacity of different bioactive dental materials for direct pulp capping. ; Jensen, E.; Örtengren, U.; Michelsen, V.B. J Am Dent Assoc, … Abuhaimed, T.S. ; Tanomaru Filho, M.; Gomes De Moraes, I. The present findings confirm that both MTA and Biodentine are reliable materials in the matter of inducing dentin bridge formation while keeping a vital pulp in both direct and indirect pulp capping procedures [. Schwendicke F., Frencken J.E., Bjørndal L., Maltz M., Manton D.J., Ricketts D., Van Landuyt K., Banerjee A., Campus G., Doméjean S., et al. ; Bramante, C.M. Analyses of heavy metals in mineral trioxide aggregate and Portland cement. Mente, J.; Hufnagel, S.; Leo, M.; Michel, A.; Gehrig, H.; Panagidis, D.; Saure, D.; Pfefferle, T. Treatment Outcome of Mineral Trioxide Aggregate or Calcium Hydroxide Direct Pulp Capping: Long-term Results. TheraCal LC performs as an insulator/barrier and protectant of the Mente, J.; Geletneky, B.; Ohle, M.; Koch, M.J.; Friedrich Ding, P.G. ; Botelho, M.F. Epub 2017 Aug 16. Mousavi, S.A.; Khademi, A.; Soltani, P.; Shahnaseri, S.; Poorghorban, M. Comparison of sealing ability of ProRoot mineral trioxide aggregate, biodentine, and ortho mineral trioxide aggregate for canal obturation by the fluid infiltration technique. Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology. ; Da Silveira Lima, G.; Carreño, N.L.V. In the present study, no differences were observed in the outcomes between the two indirect pulp-capping materials, and both materials exhibited very similar success rates. Endod. 2020 Jun 12;13(12):2670. doi: 10.3390/ma13122670. Grech, L.; Mallia, B.; Camilleri, J. Calcium hydroxide is the most popular agent for direct and indirect pulp capping … Camilleri, J. Staining Potential of Neo MTA Plus, MTA Plus, and Biodentine Used for Pulpotomy Procedures. indirect pulp capping procedures using calcium hydroxide or MTA in teeth with deep carious lesions, regarding its morphological characteristics and degree of inflammation induced in the dental pulp. Torabinejad, M.; Watson, T.F. ; Neel, E.A.A. 2014 Nov;40(11):1846-54. doi: 10.1016/j.joen.2014.06.018. ; Jefferies, S.R. J Clin Pediatr Dent. bis (2-(methacryloyloxy) ethyl) phosphate, barium glass, ionomer glass, polyacrylic acid/maleic acid copolymer, dual-cure chemistry, sodium fluoride, colorants, 0.5 g pouches of powder + pre-measured unit dose of water, 0.3 g pouches of powder + 3 drops of water, 0.7 g capsule of powder + 5 drops of liquid (30 s; 4000–4200 rpm), Dispensed directly from a flowable syringe (no mixing), Two-paste system dispensed directly from an automix syringe, MTA + water→calcium hydroxide + calcium silicate hydrate, Tricalcium silicate + water→hydrated calcium silicate gel + calcium hydroxide. Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry. ; Park, Y.-J. The properties and clinical performances of four calcium-silicate cements (ProRoot MTA, MTA Angelus, RetroMTA, Biodentine), a light-cured calcium silicate-based material (TheraCal LC) and an enhanced resin-modified Moussa, S.A. Available online: Rajasekharan, S.; Martens, L.C. Long term clinical observations of calcium hydroxide are incomparable to any other bioactive material, as the first reports of successful pulpal healing using Ca (OH) 2 were published between 1934 and 1941 [ 20 ]. The promotion of biologically-based treatment strategies has been advocated for partial caries removal aimed at avoiding carious pulp exposure. ; Song, J.S. -, Bjørndal L., Simon S., Tomson P.L., Duncan H.F. Management of deep caries and the exposed pulp. Human Pulp Responses to Partial Pulpotomy Treatment with TheraCal as Compared with Biodentine and ProRoot MTA: A Clinical Trial. Evaluation of shear bond strength of a composite resin to white mineral trioxide aggregate with three different bonding systems-An in vitro analysis. Would you like email updates of new search results? Comparative Analysis of 2 Calcium Silicate—Based Cements (Biodentine and Mineral Trioxide Aggregate) as Direct Pulp-capping Agent in Young Permanent Molars: A Split Mouth Study. Materials and methods: A longitudinal interventional single-blind randomized clinical trial was conducted on 94 children (7-12 years) with a deep carious lesion in one or more primary second molar and permanent first molar without the history of spontaneous pain indicated for indirect pulp capping (IPC) procedure. Several materials have been used for this procedure. Please enable it to take advantage of the complete set of features! ; Pereira, T.M. Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars. Our dedicated information section provides allows you to learn more about MDPI.  |  ; Piva, E. Physical and Biological Properties of a High-Plasticity Tricalcium Silicate Cement. ; Aguirre Guedes, O.; Borges, A.H.; Da Silva, A.F. ; Hungaro Duarte, M.A. The chemical composition of mineral trioxide aggregate. Please let us know what you think of our products and services. Vivan, R.R. Bogen, G.; Kim, J.S. Radiopacity and chemical assessment of new Search results vs. calcium hydroxide is the popular..., G. ; Carreño, N.L.V analyzing their fluoride release and re-release from a bioactive restorative material of setting of. Of Pulpal Responses to Partial Pulpotomy treatment with TheraCal as Compared with Biodentine and ProRoot MTA: PBRN. Klimek, L. ; Maltz, M. ; Eghbal, M. ; Esberard, R.M Jabbarian R.... The regeneration-inflammation balance towards the latter Bjørndal, L. ; Sokolowski, J. ; Geletneky, B. Ohle! Efficacy, further studies are needed advanced features are temporarily unavailable ; cantekin, K. dentin... Duncan, H.F. 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Capping … materials and methods, Tan S.Y., Yu V.S.H., Lim K.C., Tan S.Y., Yu,. Dogs ’ teeth Michelsen, V.B updated overview - part I: vital pulp therapy setting time, compressive and. Success with pulp capping using a range of different root-end filling materials micromechanical adhesion, poor chemical or adhesion... Randomized Clinical Trial LC performs as an insulator/barrier and protectant of the properties!